ASSESSMENT OF RADIOLOGICAL PATHOLOGY USING MRI OR CT SCAN OR X-RAY

Description

Pathology is the study of the causes and effects of disease or injury. Nowadays, magnetic resonance imaging (MRI) has developed into the most important tool for the diagnosis and monitoring many illness such multiple sclerosis (MS). Its high sensitivity for the evaluation of inflammatory and neurodegenerative processes in the brain and spinal cord has made it the most commonly used technique for the evaluation of patients with MS. Moreover, MRI has become a powerful tool for treatment monitoring, safety assessment as well as for the prognostication of disease progression. Clinically, the use of MRI has increased in the past couple decades as a result of improved technology and increased availability that now extends well beyond academic centers. Consequently, there are numerous studies supporting the role of MRI in the management of patients with MS. The aim of this work is to study the latest insights into the utility of MRI in MS.

 

CHAPTER ONE

1.0                                          INTRODUCTION

1.1                            BACKGROUND OF THE STUDY

The diagnosis of multiple sclerosis (MS) is based upon a clinical assessment; despite significant effort, no single biomarker has been found to independently confirm the diagnosis. In an attempt to assure the highest sensitivity and specificity, a set of guidelines, referred to as the McDonald criteria, (McDonald WI, Compston A, Edan G, et al, 2001) utilizes magnetic resonance imaging (MRI) to provide supportive data to facilitate the diagnosis of MS. MRI has been part of the International Panel criteria for the diagnosis of MS since 2001, and its use has become increasingly vital as reflected in the last changes by the committee guidelines in 2010. According to Selchen D (2012) MRI has been elevated to an essential nonclinical tool for the detection of early MS, for which it may provide concomitant criteria of dissemination in time and space at an initial clinical event, facilitating an established diagnosis of relapsing–remitting MS (RRMS) early within the disease course.

Aside from being an invaluable tool for the diagnosis of MS, MRI has also become a fundamental part of the routine medical management of an individual patient with MS. The concept of predicting disease progression has gained more importance, and the impact of T1-hypointense lesions, T2-hyperintense lesion load as well as regional and general atrophy will be discussed.

Moreover, MRI has developed a crucial role for the assessment of treatment response, especially in an era with a multitude of new medications with varying levels of efficacy. With the introduction of different and often very potent immunosuppressive medications, MRI has found a role in monitoring for potential safety concerns associated with treatment. Lastly, more advanced MRI modalities may provide insight into the pathogenesis of the disease, novel treatment targets and improved diagnostics; the potential applications of nonconventional MRI for MS will be briefly discussed.

1.2                                   PROBLEM STATEMENT

There are many illnesses that cannot be easily detected by just physical observation in the hospital such as multiple sclerosis (MS). The use of radiological technology has made this very simple in that it captures the image, diagnoses and monitors illness. MRIs can be used to get images of the brain and spinal cord, bones, the heart, blood vessels and different internal organs.

1.3                     AIM AND OBJECTIVES OF THE STUDY

The aim of this work is to study the latest insights into the use of MRI in MS, especially with respect to diagnosis and monitoring of disease activity. Special focus is also put on the evaluation of treatment efficacy and safety. At the end of this work student involved shall be able to study and understand the function, operation and application of magnetic resonance in the study of the causes and effects of disease or injury.

1.4                                             LIMITATION OF THE STUDY

There are many application radiological technologies in diagnosis and monitoring of illness. This study limited the use of magnetic resonance imaging (MRI) in diagnosis and monitoring of multiple sclerosis (MS)

1.5                                                   SCOPE OF THE STUDY

A magnetic resonance imaging scan, more commonly known as an MRI scan, is a detailed cross-sectional image of a part of the body. It is similar to a CT scan, but has a higher quality, so it is easier to see differences in tissues. Utilization of MRI has facilitated the diagnosis of MS, and has simplified the decision making as to when disease-modifying treatment should be initiated. However, there remains a need for standardization of MRI acquisition methods to advance patient care and to reach comparable results between centers. Improved and updated MRI protocols have been proposed by various expert panels and the most recent guidelines were created by the MRI in MS (MAGNIMS) consortium in 2015.The following paragraphs will summarize the technical recommendations for the diagnostic workup for MS, given by the MAGNIMS steering committee.

1.6                                 PROJECT ORGANISATION

The work is organized as follows: chapter one discuses the introductory part of the work, chapter two presents the literature review of the study, chapter three describes the methods applied, chapter four discusses the results of the work, chapter five summarizes the research outcomes and the recommendations.